Accessibility

I want to find

Close

Breast Cancer Genes

BRA1, BRA2, PTEN and TP53

Every day, breast cancer scientists and researchers learn more about genes linked to breast cancer. Hereditary breast cancer accounts for 5% to 10% of all breast cancer cases.

Some breast cancer genes include:

  • BRCA1 and BRCA2 genes: These are tumor suppressor genes that usually have the job of controlling cell growth and cell death. Changes to their structure may cause cancer tumors to grow. Most cases of hereditary breast cancer are linked to this gene. They contribute to others types of cancer, especially ovarian cancer.
  • PTEN gene: This gene helps control cell growth and death. Damage to this gene creates a higher risk for both cancerous and noncancerous breast tumors. It can also lead to tumors in the thyroid, digestive tract, endometrium, and ovaries, often at a young age.
  • TP53 gene: This gene tells cells to make a protein called p53, which helps stop the growth of abnormal cells. Changes in TP53 cause an increased risk of breast cancer, leukemia, brain tumors, and childhood sarcomas. Less than 1% of all breast cancer is thought to be related to this gene.

What are your risk factors?

Talk with your health care provider about your breast cancer risk factors and what you can do about them. Tools can be used to help estimate your risk, allowing you to set up a personalized prevention and screening plan.

Find a physician to discuss your breast cancer risk factors or recommend a genetic counselor.

Should You Have Genetic Testing for Breast Cancer?

Genetic testing for cancer should strongly be considered in people with all of the following:

  • A personal or family history that suggests a hereditary cancer syndrome is present, such as:
    • Cancers have been found at unusually young ages
    • Several close relatives who have had the same kind of cancer
    • One person has had multiple types of cancer
    • Cancer has been diagnosed in both organs when organs are found in pairs, such as both breasts or both kidneys
    • There's evidence of other birth defects that are linked to certain cancer syndromes
    • Other family members have been tested and have genetic mutations that are linked to cancer
    • A genetic test is available and has been proven to be accurate
    • The results of testing can help the person make decisions about medical care

If you are considering genetic testing, talk to a professional about it. It's important to understand the limitations of genetic testing and how the test results might be used before testing. You also need to discuss the costs and whether your health insurance will help pay for testing.

Getting tested can result in complex, emotional issues. If you test positive, you may face difficult decisions about treatments to prevent cancer. You may have increased fear and anxiety about developing cancer. You may have concerns about losing your health insurance coverage. If you test negative, you may also face difficult challenges, such as survivor guilt, if other family members have tested positive.

However, if you are anxious or considering treatments such as preventive surgery based on your family history, having the results may be empowering. Because of these issues, you should seek genetic counseling before, during, and after any genetic testing. Our genetic counselors can talk with you about what a particular test will or will not tell you, and give you insights into the testing process.

Patient Stories

  • “We told Grace to feel her feelings and then look for the bright spot, rise up and move forward,” added mom Aubrey. “By encouraging Grace to bounce to the bottom and then come back up, she was able to truly feel the hardship and then consciously turn it ...

    Grace
    Read More
  • “The team at Community Medical Center was phenomenal. I have only good things to say about each of the doctors.”

    Sharon
    Read More

Patient Stories

  • Watch Testimonial
  • Watch Testimonial
Saint Barnabas Medical Center
94 Old Short Hills Road
Livingston, NJ 07039
(973) 322-5000
View
Monmouth Medical Center
300 Second Avenue
Long Branch, NJ 07740
(732) 222-5200
View
The Unterberg Children's Hospital at Monmouth Medical Center
300 Second Avenue
Long Branch, NJ 07740
(732) 923-7250
View
Monmouth Medical Center Southern Campus
600 River Avenue
Lakewood, NJ 08701
(732) 363-1900
View
Clara Maass Medical Center
1 Clara Maass Drive
Belleville, NJ 07109
(973) 450-2000
View
Community Medical Center
99 Highway 37 West
Toms River, NJ 08755
(732) 557-8000
View
Newark Beth Israel Medical Center
201 Lyons Avenue at Osborne Terrace
Newark, NJ 07112
(973) 926-7000
View
Children's Hospital of New Jersey at Newark Beth Israel Medical Center
201 Lyons Avenue at Osborne Terrace
Newark, NJ 07112
(973) 926-7000
View
Jersey City Medical Center
355 Grand Street
Jersey City, NJ 07302
(201) 915-2000
View
The Bristol-Myers Squibb Children's Hospital at RWJUH
200 Somerset Street
New Brunswick, NJ 08901
(732) 828-3000
View
RWJ University Hospital Hamilton
1 Hamilton Health Place
Hamilton, NJ 08690
(609) 586-7900
View
Robert Wood Johnson University Hospital
1 Robert Wood Johnson Place
New Brunswick, NJ 08901
(732) 828-3000
View
RWJ University Hospital Rahway
865 Stone Street
Rahway, NJ 07065
(732) 381-4200
View
RWJ University Hospital Somerset
110 Rehill Avenue
Somerville, NJ 08876
(908) 685-2200
View
The Jacqueline M. Wilentz Breast Center at Howell
4013 Route 9
Suite 2S
Howell, NJ 07731
(732) 923-7700
View
The Jacqueline M. Wilentz Breast Center at Lakewood
600 River Ave
Lakewood, NJ 08701
(732) 923-7700
View
Medical Specialty Services at Bayonne
16 East 29th Street
Bayonne, NJ 07002
(973) 926-7280
View
The Jacqueline M. Wilentz Breast Center at Colts Neck
310 Route 34 South
Second Floor
Colts Neck, NJ 07722
(732) 923-7700
View
The Jacqueline M. Wilentz Breast Center at Monmouth Medical Center
300 Second Avenue
Long Branch, NJ 07740
(732) 923-7700
View
Cristie Kerr Women's Health Center
377 Jersey Avenue
Ground Floor, Medical Office Building
Jersey City, NJ 07302
(877) 393-5374
View
Center for Breast Health and Disease Management - Westfield
560 Springfield Ave
Westfield, NJ 07090
(973) 322-7020
View
Center for Breast Health and Disease Management - Metuchen
173 Essex Ave
Metuchen, NJ 08840
(732) 494-0415
View
Center for Breast Health and Disease Management - Livingston
200 South Orange Avenue
Suite 102
Livingston, NJ 07039
(973) 322-7020
View
Rutgers Cancer Institute of New Jersey
195 Little Albany St.
New Brunswick, NJ 08901
(732) 235-2465
View
The Family Health Center (FHC) at Newark Beth Israel Medical Center
166 Lyons Avenue
Newark, NJ 07112
(973) 926-7300
View
Community Medical Center Women's Imaging Center - Toms River
368 Lakehurst Rd
1st Floor
Toms River, NJ 08755
(732) 557-8146
View
Barnabas Health Ambulatory Care Center
200 South Orange Avenue
Livingston, NJ 07039
(973) 322-7000
View
Monmouth Medical Center Outpatient Infusion Center
100 State Route 36 West
West Long Branch, NJ 07764
(732) 923-6575
View
Eric B. Chandler Health Center at Rutgers Robert Wood Johnson Medical School
277 George Street
New Brunswick, NJ 08901
(732) 235-6700
View
Eric B. Chandler Health Center Church St. Annex
123 Church Street
New Brunswick, NJ 08901
(732) 235-2052
View
Rutgers Robert Wood Johnson Medical Group at Monroe
800 Bunn Drive
Suite 303
Princeton, NJ 08540
(609) 655-5178
View
Rutgers Robert Wood Johnson Medical Group
18 Centre Drive
Clinical Academic Building (CAB)
New Brunswick, NJ 08901
(609) 655-5178
View
Cancer Center at RWJ Hamilton
2575 Klockner Road
Hamilton Township, NJ 08690
(609) 631-6960
View
RWJUH Lab Services at Rutgers Cancer Institute of New Jersey
195 Little Albany Street
First Floor
New Brunswick, NJ 08901
(732) 937-8588
View
Rutgers Robert Wood Johnson Medical School
125 Paterson Street.
Clinical Academic Building (CAB)
New Brunswick, NJ 08901
(732) 235-6200
View

Cancer Treatment & Care

offered at these locations in your neighborhood

View All Locations