• At A Glance
  • Education & Publications
  • Hospital Affiliations
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    Bio
    Steven K. Libutti, MD, FACS serves as Senior Vice President of Oncology Services for RWJBarnabas Health and is Director of the Rutgers Cancer Institute of New Jersey and Vice Chancellor for Cancer Programs, Rutgers Biomedical and Health Sciences.

    He is also a Professor of Surgery at Rutgers Robert Wood Johnson Medical School and an Affiliated Distinguished Professor in Genetics at the Rutgers School of Arts and Sciences Department of Genetics.

    Most recently, Dr. Libutti served as Director for the Montefiore Einstein Center for Cancer Care in New York City and was a Professor and Vice Chairman of the Department of Surgery and Professor in the Department of Genetics at Albert Einstein College of Medicine and Montefiore Health System. A surgical oncologist, Dr. Libutti is an internationally known expert in endocrine surgery and the management of neuroendocrine tumors. He is the immediate Past President of the American Association of Endocrine Surgeons. His clinical practice focuses on gastrointestinal malignancies including cancers of the liver and pancreas.

    The recipient of funding from the National Cancer Institute (NCI) for the past 20 years, Dr. Libutti is also a researcher whose work focuses on developing novel cancer therapies through an understanding of the tumor microenvironment and blood vessel formation in tumors. He is studying tumor neovascular formation and the interaction between tumor cells, endothelial cells and the components of the tumor microenvironment including fibroblasts and cancer stem cells. His work also focuses on a better understanding of the tumor suppressor genes MEN1 and FILIP1L.

    After graduating magna cum laude from Harvard College, Dr. Libutti received his medical degree from the College of Physicians and Surgeons of Columbia University. He remained at Presbyterian Hospital in New York where he completed his residency in surgery, followed by a fellowship at the NCI in surgical oncology and endocrine surgery. He continued at the NCI where he became a tenured Senior Investigator and Chief of the Tumor Angiogenesis Section in the Surgery Branch.  He has published over 280 peer reviewed journal articles, is Editor-in-Chief of the Nature Journal Cancer Gene Therapy, and holds seven U.S. patents.

    Patents

    Bass LS, Libutti SK, Eaton AM, Tissue bonding and sealing composition and methods of using the same, U. S. Patents 5,209,776 and 5,292,362.

    Stern D, Clauss M, Kao J, Kayton ML, Libutti SK, Antibody which specifically binds to endothelial monocyte activating polypeptide II, U.S. Patent 5,641,867.

    Stern D, Clauss M, Kao J, Kayton ML, Libutti SK, Endothelial monocyte activating polypeptide II: a mediator which activates host response, U.S. Patents 6,228,837 and 6,734,168.

    Libutti SK, Zeiger MA, Mazzanti C, Umbricht C, Diagnostic tool for diagnosing benign versus malignant thyroid lesions, U.S. Patent 7,901,881.

    Libutti SK, Kwon M, Tandle A, FILIPIL compositions and methods for treating cancer, U.S. Patent 8,501,912.

    Libutti SK, He M, Molecular-based method of cancer diagnosis and prognosis, U.S. Patents 8,715,928, and 9,181,589.

    Libutti SK, Yuan Z, Combination therapy using a targeted inducer of apoptosis combined with an inhibitor of inhibitor of apoptotic proteins (IAP’s) for the treatment of cancer, U.S. Patent Pending, U.S. Serial No. 61/537,250.

    Related Articles
    Clinical Interests

    Neuroendocrine tumors, thyroid cancer, parathyroid tumors, pancreatic cancer, liver cancer, gastrointestinal (GI) cancers, minimally invasive surgery, and clinical trials.

  • Medical School

    Columbia Univ College of Physicians and Surgeons, New York, NY

    Internship

    New York Presbyterian Columbia University Medical Center, New York, NY

    Residency

    New York Presbyterian Columbia University Medical Center, New York, NY

    Fellowship

    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD

    Publications
    • Title:Evaluation and management of pancreatic lesions in patients with von Hippel-Lindau disease
      Authors:Keutgen XM, Hammel P, Choyke PL, Libutti SK, Jonasch E, Kebebew E.
      Publisher:Nat Rev Clin Oncol
      Date:2016
      Issue:
      Description: doi: 10.1038/nrclinonc.2016.37. [Epub ahead ofprint] Review. PubMed PMID: 27030075.
    • Title:The value of FDG-PET in the staging of gastric adenocarcinoma: A single institution retrospective review
      Authors:Serrano OK, Love C, Goldman I, Huang K, Ng N, Abraham T, Da Silva R, Friedmann P, Libutti SK, Kennedy TJ
      Publisher:J Surg Oncol
      Date:2016
      Issue:113(6):640-6
      Description:doi: 10.1002/jso.24190. PubMed PMID: 27115836
    • Title:Reduced expression of FILIP1L, a novel WNT pathway inhibitor, is associated with poor survival, progression and chemoresistance in ovarian cancer
      Authors:Kwon M, Kim JH, Rybak Y, Luna A, Hun Choi C, Chung JY, Hewitt SM, Adem A, Tubridy E, Lin J, Libutti SK
      Publisher:Oncotarget
      Date:2016
      Issue:
      Description: doi: 10.18632/oncotarget.12784. [Epub ahead of print] PubMed PMID: 27776341.
    • Title:Editorial: Treatment decision making in the era of genetic testing and molecular diagnostics
      Authors:Libutti SK
      Publisher:Surgery
      Date:2017
      Issue:161(1):228-229
      Description:doi: 10.1016/j.surg.2016. 10.009. PubMed PMID: 27863788
    • Title:Of mice and men(in) and what I have learned from both
      Authors:Libutti SK
      Publisher:Surgery
      Date:2017
      Issue:161(1):1-11
      Description:doi: 10.1016/j.surg.2016.10.004. PubMed PMID: 27865595.
    • Title:32-Phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect
      Authors:Chandra D, Selvanesan BC, Yuan Z, Libutti SK, Koba W, Beck A, Zhu K, Casadevall A, Dadachova E, Gravekamp C
      Publisher:Oncotarget
      Date:2017
      Issue:
      Description: doi: 10.18632/oncotarget.15117. [Epub ahead of print]. PubMed PMID: 28186976.
    • Title:Sensitivity of 3-Dimensional Sonography in Preoperative Evaluation of Parathyroid Glands in Patients With Primary Hyperparathyroidism
      Authors:Frank SJ, Goldman-Yassen AE, Koenigsberg T, Libutti SK, Koenigsberg M
      Publisher:J Ultrasound Med.
      Date:2017
      Issue:
      Description:doi: 10.1002/jum.14245. [Epub ahead of print] PubMed PMID: 28543268
    • Title: Everolimus in Neuroendocrine Tumors of the Gastrointestinal Tract and Unknown Primary
      Authors:Singh S, Carnaghi C, Buzzoni R, Pommier RF, Raderer M, Tomasek J, Lahner H, Valle JW, Voi M, Bubuteishvili-Pacaud L, Lincy J, Wolin E, Okita N, Libutti SK, Oh DY, Kulke M, Strosberg J, Yao JC, Pavel ME, Fazio N
      Publisher:Neuroendocrinology, RAD001 in Advanced Neuroendocrine Tumors, Fourth Trial (RADIANT-4) Study Group
      Date:2017
      Issue:
      Description:doi: 10.1159/000477585. [Epub ahead of print.] PubMed PMID: 28554173
    • Title:Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas
      Authors:Wang H, Bender A, Wang P, Karakose E, Inabnet WB, Libutti SK, Arnold A, Lambertini L, Stang M, Chen H, Kasai Y, Mahajan M, Kinoshita Y, Fernandez-Ranvier G, Becker TC, Takane KK, Walker LA, Saul S, Chen R, Scott DK, Ferrer J, Antipin Y, Donovan M, Uzilov A
      Publisher:Nat Commun.
      Date:2017
      Issue:3;8(1): 767
      Description:doi: 10.1038/s41467-017-00992-9. PubMed PMID: 28974674
    • Title:Phase II Study of BEZ235 versus Everolimus in Patients with Mammalian Target of Rapamycin Inhibitor-Naïve Advanced Pancreatic Neuroendocrine Tumors
      Authors:Salazar R, Garcia-Carbonero R, Libutti SK, Hendifar AE, Custodio A, Guimbaud R, Lombard-Bohas C, Ricci S, Klümpen HJ, Capdevila J, Reed N, Walenkamp A, Grande E, Safina S, Meyer T, Kong O, Salomon H, Tavorath R, Yao JC
      Publisher:The Oncologist
      Date:2017
      Issue:
      Description:pii: theoncologist.2017-0144. doi: 10.1634/theoncologist.2017-0144. [Epub ahead of print] PubMed PMID: 29242283
    • Title:Association of VHL Genotype With Pancreatic Neuroendocrine Tumor Phenotype in Patients With von Hippel-LindauDisease
      Authors:Tirosh A, Sadowski SM, Linehan WM, Libutti SK, Patel D, Nilubol N, Kebebew E
      Publisher:JAMA Oncol.
      Date:2018
      Issue:4(1):124-126
      Description:doi:10.1001/jamaoncol.2017.3428. PubMed PMID: 29075773
    • Title:Injection of bulking agents for laryngoplasty
      Authors:Snyder SK, Angelos P, Carty SE, Doherty GM, Howe JR, Lee JA, Libutti SK, Miller BS, Parangi S, Patel KN, Sippel RC, Sturgeon C, Wang TS, Yip L, Zeiger MA
      Publisher:Surgery
      Date:2018
      Issue:163(1):6-8
      Description:doi: 10.1016/ j.surg.2017.08.019. Epub 2017 Nov 9. PubMed PMID: 29129367
    • Title:Development of a Method to Implement Whole-Genome Bisulfite Sequencing of cfDNA from Cancer Patients and a Mouse Tumor Model
      Authors:Maggi EC, Gravina S, Cheng H, Piperdi B, Yuan Z, Dong X, Libutti SK, Vijg J, Montagna C
      Publisher:Front Genet.
      Date:2018
      Issue:23;9:6
      Description:doi: 10.3389/fgene.2018.00006. eCollection 2018. PMID: 29410677