Trinitas Cancer Clinical Trials

What are Clinical Trials?

Also called research studies, clinical trials are designed to assess potential new treatment or prevention opportunities with the goal of better outcomes. Clinical trials test the safety and efficiency of new or transformed cancer drugs, doses, unique approaches to surgery or radiation therapy, and diversified treatment combinations. The goal of a clinical trial may be to cure more patients, to prolong the lives of more patients, to prevent the spread or recurrence of cancer, or to achieve the same outcome as previous therapies with fewer side effects.

Clinical trials are a significant component for enhancing the treatment of medical conditions because they lead to exceeding standards of care. Every current medical treatment was a clinical trial at one point. In fact, current standard treatments for particular cancers may not be what is optimal for you, so always discuss with your oncologist about what clinical trial might be appropriate to consider for your specific cancer.

What are the Benefits of Clinical Trials?

Designed to evaluate the effectiveness of new treatment interventions, clinical trials have several benefits such as:

• Exceptional cancer care
• The possibility of benefiting from a new drug or treatment procedure
• The opportunity to help other patients and improve cancer treatment

It has been proven that clinical trials have offered some of the most effective cancer treatments currently available today.

What are the types of Clinical Trials?

Also known as "research protocols" clinical trials evaluate the effectiveness of new interventions. The following are the various types of cancer clinical trials:

• Prevention trials constructed to keep cancer from developing in patients who have not previously had the disease
• Prevention trials designed to prevent a new type of cancer from developing in those who have had cancer
• Early detection trials to discover cancer in its early stage
• Treatment trials to examine new therapies in people who have cancer or to compare new, promising treatment to customary, established treatment
• Quality-of-life studies to enhance comfort and quality of life for people with cancer
• Studies to evaluate ways of altering cancer-causing behaviors such as tobacco use

Who Can Participate in Clinical Trials?

Trinitas Cancer Center has many clinical trials available for patients with various types and stages of cancer. Any patient interested in participating in one of these trials is carefully screened. In order to take part in the study, the patient must have specific medical conditions as well as meet particular standards to qualify for treatment in the protocol.

These standards, referred to as eligibility criteria, are for the patient's safety. These criteria will ensure that the results of the study will be useful when selecting treatments for other patients with similar diseases.

About Our Approach

As part of our commitment to providing the most thorough care, Trinitas Comprehensive Cancer Center participates in clinical trials to test new medications and other advances in treatment and technology. Because we believe that patients should have access to as many treatment options as possible, our highly accomplished and board certified oncologists encourage patients to participate in clinical trials when the most appropriate treatment is a trial with a new compound.

As part of the Eastern Cooperative Oncology Group (ECOG), our Comprehensive Cancer Center is part of a larger network of cancer centers that partake in clinical research being conducted by major pharmaceutical and biotechnology companies. The range of choices has expanded dramatically for patients who want to evaluate every possible option available to them. New drugs, updated drug delivery methods and immunotherapy are part of what we offer at the Trinitas Comprehensive Cancer Center.

Trinitas staffs medical oncologists that are experienced in most forms of cancer. These oncologists work with a team of professionals including radiation oncologists when appropriate, advanced practice nurses, oncology certified and trained nurses, a clinical research manager, nutritionists and social workers in order to provide accessible, personalized and compassionate care for all of our patients.

Clinical Trials Open To Enrollment at TCCC

Breast Cancer
NRG-BR003: A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer.

Breast Cancer
S1207: Hormone Therapy with or without Everolimus in Treating Patients with Breast Cancer

Breast Cancer
Alliance A011401: "BWEL" Randomized Phase III Trial Evaluating the Role of Weight Loss in Adjuvant Treatment of Overweight and Obese Women with Early Breast Cancer

Chronic Lymphocytic Leukemia
informCLL (TM) A Disease Registry for Patients with Chronic Lymphocytic Leukemia

Cancer Experience Registry
Anyone who has ever received a cancer diagnosis, whether recently diagnosed, in treatment, or years post-treatment can participate

Biospecimen
Collection and Distribution of Remnant and Research Use Only Biospecimens for Novel Research Uses

Paradigm Registry
A Prospective Registry Study to Evaluate the Efficacy of Precision Molecular Testing in the Treatment of Advanced Solid Tumors

Advanced Solid Cancer
A Phase 1/1b Study of MGCD516 in Patients With Advanced Solid Tumor Malignancies

Breast Cancer
Elacestrant Monotherapy for the Treatment of ER+/HER2- Advanced Breast Cancer Following CDK4/6 Inhibitor Therapy: A Phase 3 Randomized, Open-Label, Active- Controlled, Multicenter Trial (EMERALD)

Breast Cancer
A Multinational, Multicenter, Randomized, Phase 3 Study of Tesetaxel plus a Reduced Dose of Capecitabine versus Capecitabine Alone in Patients with HER2 Negative, Hormone Receptor Positive, Locally Advanced or Metastatic Breast Cancer Previously Treated with a Taxane

Pancreatic
A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared with FOLFOX Alone as Second-line Therapy in Patients with Metastatic Pancreatic Cancer that has Progressed During or Following a First-Line Gemcitabine Containing Regimen

Breast Cancer
SWOG 1416: Phase II Randomized Placebo-Controlled Trial of Cisplatin with or Without ABT-888 (Veliparib) in Metastatic Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer

Breast Cancer
A011502: A Randomized, Phase III, Double Blinded, Placebo Controlled Trial of Aspirin as Adjuvant Therapy for Node Positive HER2- Breast Cancer: The ABC Trial

Multiple Primary Cancers
EAY131: Molecular Analysis for Therapy Choice (MATCH)

Multiple Primary Cancers
EAQ152: Communication and Education in Tumor Profiling: A Randomized Study of Pre-Disclosure Genetic Education v. Usual Care in Tumor Profiling for Advanced Cancer and a Pilot Study of Remote Genetic Counseling for Participants with Potential Germline Mutations Identified on Tumor Profiling (COMET)