Important Update: Masking and visitation guidelines have been updated.
Click here for details >>
I want to find
To collect long-term follow-up data on delayed adverse events after administration of cilta-cel, and to characterize and understand the long-term safety profile of cilta-cel.
Protocol Number: 012204
Principal Investigator: Matthew Matasar
Phase: N/A
Scope: National
Applicable Disease Sites: Multiple Myeloma
Read Inclusion & Exclusion Criteria
Please note that we have obtained the inclusion and exclusion criteria information from the National Institutes of Health’s clinical trials web site www.clinicaltrials.gov. The listed criteria may not necessarily reflect recent amendments to the protocol and the current criteria.
For further information about clinical trials, please contact us at 732-235-7356 or 844-CANCERNJ.
Primary Objectives: - To characterize the safety, toxicity, and tolerability of etentamig when co-administered with iberdomide in subjects with RRMM. - To determine the recommended doses of etentamig and iberdomide combination treatment in subjects with RRMM. Secondary Objectives: - To evaluate the preliminary anti-MM activity of etentamig when co-administered with Iberdomide. - To characterize the PK and the immunogenicity of etentamig, as well as the PK of iberdomide and its metabolite M12, when administered in combination as a regimen.
Protocol Number: 012502
Principal Investigator: Mansi R Shah
Phase: Phase I/II
Therapies Involved: Chemotherapy multiple agents systemic
Drugs Involved: Etentamig (ABBV-383) Iberdomide
Primary: To evaluate the efficacy of JNJ-79635322 Secondary: - To further understand the efficacy of JNJ-79635322 - To evaluate and characterize the overall safety profile of JNJ-79635322 - To assess participants symptoms, functioning and HRQoL through PROs - To characterize the PK of JNJ-79635322 - To assess the immunogenicity of JNJ-79635322
Protocol Number: 012506
Phase: Phase II
Therapies Involved: Chemotherapy single agent systemic
Drugs Involved: JNJ-79635322
Primary: - To evaluate the efficacy of BMS-986393 in participants with quadruple class exposed R/R MM having received at least 4 prior LOT. Secondary: - To further evaluate the efficacy of BMS-986393 in participants with quadruple class exposed R/R MM having received at least 4 prior LOT and 3 prior LOT.
Protocol Number: 012402
Drugs Involved: A Arlocabtagene Autoleucel (BMS-986393)
1. The primary objective is to determine if a novel fluorescent assay measuring dynamic parameters of immune synapse quality can be used to assess commercial T cell products. 2. The secondary objective is to determine if a novel fluorescent assay measuring dynamic parameters of the immune synapse can be used as a biomarker to associate with CAR-T cell efficacy and toxicity.
Protocol Number: 012108
Principal Investigator: Yun Kyoung Tiger
Scope: Local
Applicable Disease Sites: Hodgkin's Lymphoma, Multiple Myeloma, Non-Hodgkin's Lymphoma
Primary: - For phase 1, the primary objective of the study is to assess the safety, tolerability, and to determine a recommended phase 2 dose regimen (RP2DR) of linvoseltamab for phase 2 of the study. - For phase 2, the primary objectives of the study are: 1. To assess the preliminary anti-tumor activity of linvoseltamab in participants with NDMM who are eligible for HDT with ASCT (transplant-eligible) 2. To assess the preliminary anti-tumor activity of linvoseltamab in participants with NDMM who are ineligible for ASCT (transplant-ineligible)
Protocol Number: 012310
Drugs Involved: Linvoseltamab (REGN5458)
The primary objective of this study is to evaluate the efficacy of the second-generation antihistamine, loratadine, as prophylaxis for filgrastim (i.e., Neupogen, Zarxio) induced bone pain during stem cell mobilization in multiple myeloma patients. The secondary objectives are to (1) examine the frequency and quantity of supportive analgesic medications needed in addition to loratadine or placebo for filgrastim induced bone pain and (2) identify risk factors associated with developing filgrastim induced bone pain.
Protocol Number: 011910
Applicable Disease Sites: Bones and Joints, Ill-Defined Sites, Multiple Myeloma
Therapies Involved: Chemotherapy (NOS) Chemotherapy multiple agents systemic
Drugs Involved: Loratadine/Placebo Pegfilgrastim