Jan 25, 2021 Are the Pfizer and Moderna Vaccines Similar?

John F. Bonamo, M.D., MS, FACOG, FACPE, Executive Vice President and Chief Medical and Quality Officer, RWJBarnabas Health, discusses the similarities and differences between the Pfizer and Moderna vaccines. 


So, currently, we have two COVID-19 vaccines available to us. We are actually using both vaccines in the RWJBarnabas Health System.

One of those is the Pfizer vaccine and one is the vaccine from Moderna. They're very similar and they're both mRNA vaccines.

They both need two doses. The Pfizer vaccine is two doses three weeks apart and the Moderna vaccine two doses four weeks apart.

The way they act in the body is very, very similar.

We have other COVID-19 vaccines that are coming.

The Johnson & Johnson vaccine and the AstraZeneca Oxford vaccine works slightly differently, but the two vaccines that are on the market currently are very, very similar in mode of action in you.